Practical biological spread-out Bragg peak design for a carbon beam
نویسندگان
چکیده
منابع مشابه
A new model for Spread Out Bragg Peak in proton therapy of uveal melanoma
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Radiotherapy of solid tumors with charged particles holds several advantages in comparison to photon therapy; among them conformal dose distribution in the tumor, improved sparing of tumor-surrounding healthy tissue, and an increased relative biological effectiveness (RBE) in the tumor target volume in the case of ions heavier than protons. A crucial factor of the biological effects is DNA dama...
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BACKGROUND Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the Spread-Out Bragg Peak (SOBP). Towards this end, we investigated the differences in the biological effect of a high-energy proton beam on the target cells placed at different pos...
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PURPOSE To investigate the clinical implications of a variable relative biological effectiveness (RBE) on proton dose fractionation. Using acute exposures, the current clinical adoption of a generic, constant cell killing RBE has been shown to underestimate the effect of the sharp increase in linear energy transfer (LET) in the distal regions of the spread-out Bragg peak (SOBP). However, experi...
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ژورنال
عنوان ژورنال: Journal of the Korean Physical Society
سال: 2015
ISSN: 0374-4884,1976-8524
DOI: 10.3938/jkps.67.1440